Media
The influence of HIV on CD127 expression and its potential implications for IL-7 therapy
Published by Seminars in Immunology
2012 Interleukin-7 (IL-7) is critical for early T-cell development and plays an important role in T-cell homeostasis, differentiation and function. Signalling via the IL-7 receptor is dependent on the expression of its components, IL-7Rα (CD127) and IL-2Rγ (CD132) and is mediated in part by alterations in CD127 expression levels in different cell subsets.
URL: http://www.sciencedirect.com/science/article/pii/S1044532312000218
Jak/STAT and PI3K signaling pathways have both common and distinct roles in IL-7-mediated activities in human CD8+ T cells
Published by Journal of Leukocyte Biology
2014 IL-7 plays an important role in T cell survival, function, and memory cell development, yet the role of cytokine signaling pathways in these processes has not been fully elucidated. Moreover, the underlying mechanisms for the observed impairment of IL-7 activity in diseases, such as HIV infection, breast cancer, and autoimmunity, are not well understood.
Influence of female sex on hepatitis C virus infection progression and treatment outcomes
Published by European Journal of Gastroenterology & Hepatology
2016 The influence of sex on hepatitis C virus (HCV)-related outcomes is often neglected. The effects of sex on liver fibrosis progression and the effect of socioeconomic status on management are unclear.
Generalized Liver- and Blood-Derived CD8+ T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus Infection
Published by PLoS ONE
2016 Generalized CD8+ T-cell impairment in chronic hepatitis C virus (HCV) infection and the contribution of liver-infiltrating CD8+ T-cells to the immunopathogenesis of this infection remain poorly understood. It is hypothesized that this impairment is partially due to reduced CD8+ T-cell activity in response to cytokines such as IL-7, particularly within the liver. To investigate this, the phenotype and cytokine responsiveness of blood- and liver-derived CD8+ T-cells from healthy controls and individuals with HCV infection were compared.
URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157055
Complexed soluble IL-7 receptor α and IL-7 increase IL-7-mediated proliferation and viability of CD8⁺ T-cells in vitro
Published by Cellular Immunology
2015 Many soluble cytokine receptors inhibit cytokine bioactivity, while others prolong ligand activity. The biological role of an endogenous soluble form of IL-7Rα, or its therapeutic effects on CD8+ T-cells are unknown. We demonstrate that recombinant IL-7Rα-Fc, when pre-incubated with IL-7, enhances IL-7-induced CD8+ T-cell proliferation and viability of human or murine CD8+ T-cells.
URL: http://www.sciencedirect.com/science/article/pii/S0008874915000027
Biography
Dr. Crawley has been with the Chronic Diseases Program at the Ottawa Hospital Research Institute since April 2012. In addition to being a Scientist with the OHRI, she is an Assistant Professor at the University of Ottawa and Carleton University, where she teaches immunology at the undergraduate, graduate, and medical school levels. She teaches these courses in both English and French.
Crawley has earned two salary awards: a CIHR New Investigator Award and an Ontario HIV Treatment Network (OHTN) Junior Investigator Development Award. Her research is funded by the OHTN, Canadian Foundation of AIDS Research, the J.P. Bickell Medical Research Foundation and the Natural Sciences and Engineering Research Council.
Crawley received a B.Sc. in Microbiology and Immunology from McGill University in Montreal, Quebec (Canada) in 1999. In 2004, she completed a Ph.D. in Immunology with Dr. Bruce N. Wilkie in the Dept. of Pathobiology at the University of Guelph’s Ontario Veterinary College (Guelph, Ontario, Canada). She then trained as a postdoctoral fellow in Dr. Jonathan B. Angel’s laboratory at the Ottawa Hospital Research Institute, and published 10 peer-reviewed scientific research and review articles on the immunopathogenesis of HIV infection. Crawley was funded by an Ontario HIV Treatment Network (OHTN) Fellowship award and awarded a University of Ottawa Faculty of Medicine Postdoctoral Award of Excellence (2007).
Recognition/Reconnaissance
Research Funding (2011-present) | Professional
- Natural Sciences and Engineering Research Council - Ontario HIV Treatment Network - Canadian Foundation of AIDS Research - J.P. Bickell Foundation - Canadian Hepatitis C Network (student scholarships)
Postdoctoral Award of Excellence | Professional
University of Ottawa Faculty of Medicine
Postdoctoral Fellowship | Professional
Ontario HIV Treatment Network Salary award (2007-2010)
New Investigator Award | Professional
Canadian Institutes of Health Research Salary award (2013-2018)
Junior Investigator Development Award | Professional
Ontario HIV Treatment Network Salary award and Research funding (2011-2015)